A Study on the Seasonal and Topographic Variations of the Skin Color of Young Women / 대한피부과학회지

Sixty-five volunteers whose skin had never been tanned intentionally participated in this experiment. The skin colors of extensor and flexor of forearm, fore-head, and cheek were measured with Color and Color Difference Meter(Nippon Denshoku Kogyo Co. CP6R 1001-DP) which represents .kin color as 'L, a, and b in values. The L, a', and b values mean the degree of ligntness, redness, and yellowness respectively. Measurement has been performed seven times repeatedly in a year at regular intervals. From the study, the following results were obtained. ]'lexor skin of forearm showed the highest lightness in a year compared to the other regions. All of the regions examined showed the highest lightness in spring compared to the other seasons. 3. Cheek skin showed the highest redness among the four checked regions in a year. 4, All of the checked regions showed the higher redness in summer than in spring. and autumn. 5 All of the checked regions showed the lowest yellowness in May.

Congenital Syphilis: Outcomes of Offsprings from Untreated and Treated Syphilitic Mothers and Clinical Manifestations of Early Congenital Syphilis / 대한피부과학회지

A retrospective study was made of the medical records of 114 pregnant women with untreated syphilis and their offsprings, and 19 pregnant women with treated syphilis and their offsprings at Severance Hospital, Yonsei University College of Medicine during the years 1972 through 1981. We analyzed the outcornes of offsprings from both untreated and treated syphilitic mothers and the clinical manife- stations of early congenital syphilis. The results obtained were as follows: Of 30 offsprings from 30 untreated syphilitic mothers with VDRL titer below 1: 4, six(20%) had congenital syphilis, one(3%) was a stillbirth, and twenty-three were normal infants. Of 84 offsprings from 84 untreated syphilitic mothers with VDRL titer above 1: 8, fifty-six(67g) had congenital syphilis, ten(12g,) were neonatal deaths, and eighteen(21%) were stillbirths, Normal infants were not observed. The mean weight ratio of placenta to fetus was 0 29 in g8 offsprings from syphilitic mothers. The ratios were as follows: 0. 25 in 14 living infants with con- genital syphilis, 0. 27 in 5 neonatal deaths, and (), 33 in 19 stillbirths respectively. 3, Of 19 pregnant women with treated syphilis, the qualitative tests of VDRL were all reactive except for one case and the quantitatis e tests of VDRL were 1: 1 weakly reactive to 1: 4 reactive. FTA-ABS tests demonstrated reactive results in all cases. The qualitative tests of VDRL in the infeants of the treated mothers were 1: 1 weakly reactive to 1: 2 reactive and FTA-ABS tests were reactive in all cases.-countinue-

Two Cases of Malignant Histiocytosis / 대한피부과학회지

Two cases of malignant histiocytosis, in which skin involvement was a prominent finding at initial clinical presentation, are reported. 1nteresting histopathologic findings, including Langerhans granule in one case and numerous eosinophils in another, were observed. In one case remission was achieved with BACOP chemotherapy (Bleomycin, Adriamycin, Cyclophosphamide, Vincristine, and Prednisone). In the other case, the patient died nine months after the onset of the disease without any treatment.

Serologic Tests for Syphilis : Comparison of a Treponema Pallidum Hemagglutination Test (TPHA) with the VDRL and FTA - ABS Tests / 대한피부과학회지

On a total 375 sera with reactive results on VDRL and/or FTA-ABS test(s), derived from severance Hospital, qualitative and quantitative TPHA tests were carried out. The objectives of the present study were to compare the result of VDRL, FTA-ABS and TPHA teats in different syphilis stages, and to as sess the suitability of the TPHA test as a screening test for syphilis. The results are summarized as follows: 1. The sensitivity of VDRL test was poor compared with TPHA and FTA-ABS tests except in secondary syphilis. 2. The FTA-ABS test(10Qp,) was more sensitive than the TPHA test(86g) in primary syphilis, but it is time consuming and costly. 3 The TPHA titers were relatively low in primary syphilis. 4, Below 1: 32Q in TPHA titer, the percentage of sera from patients tested over 1 year(64%) after the completion of treatment was higher than within 1 year(41%). The TPHA test showed 77%. agreement with VDRL test and 89% agreement with FTA-ABS test. The VDRL test is easy to perform and economic, but it showed poor effeetiveness as screening test for the detection of syphilis. On the other hand the TPHA test had a wide spectrum of reactivity in different stages of syphilis and was easy to perform. So on the basis of the results presented, we concluded that the TPHA test provides a very effective screen for syphilis.

An Experimental Study on Sweat Secretion During 2 Hours of Heat Exposure / 대한피부과학회지

Impaired sweating reportedly has been associated with a high incidence of heat pyrexia. An important cause is attributed to sweat gland fatigue following intense prolonged sweating. For further investigation, sweat gland fatigue was induced by heat exposure for 2 hours in a hot room (dry bulb 46c, wet bulb 37c) with 9 healthy subjects. Sweating rate of the right forearm increased progressively for the first 45 minutes with a maximum value of 40.0mg/4. 91 cm2/15 min followed by a slow decrease to 24.9 mg/4.91cm2/15 min at the end of 2 hours. Active sweat pores decreased in number following 2 hours of heat exposure but the differences were not significant statistically. In spite of the higher sweat rate on the back, the number of active sweat pores was smaller as compared to the right forearm. Na+ concentrations of the second hour sweat collections were higher than those of the first hour with difference of 14. 9 mEq/l on the right forearm and 12.3 mEq/1 on the back.

A Study on the Changes of the Skin Color of Korean Male Students in Summer / 대한피부과학회지

This study was undertaken to clarify whether the color changes of skin in summer are remarkable or not. The skin color of abdomen, extensor and flexor of forearm, forehead, and cheek were measured in 27 health male students who had never tanned their skin intentionally during this experiment with Color and Color Difference Meter(Nippon Denshoku Kogyo Ca. CP6R 1001-DP) which represents skin color as 'L', 'a', and 'b' values. The 'L', 'a', and 'b' values mean the degree of lightness, redness, and yellowness respectively. Measurements had been performed four times repeatedly from summer(june) to auturmn(October) with intervals of 6 weeks. The obtained values were evaluated with statistical method, and the results were sumrnarized as follows: l. Abdominal skin showed no significant color changes in this experiment. 2 Extensor and flexor skin of forearm showed significant decrease in lightness from July, and the degree of decrease was more remarkable on extensor skin than on flexor skin. The lighteness had not been recovered by October on extensor skin and by September on flexor skin. There was no significant change in redness and yellowness on both places in this experiment. 3. Forehead skin showed no significant change in lightness and yellowness in this experiment, and showed transient decrease in redness in July. 4. Cheek skin showed no significant change in lighteness and redness in this experiment, and showed transient increase in yellowness in October.

The Effect of Combination Treatment with Oral Etretinate (Ro 10 - 9359) and Vitamin E on Psoriasis Vulgaris / 대한피부과학회지

Etretinate(Ro 10-9359), an aromatic analogue of vitamin A acid, has been known to be effective in the treatment of psoriasis, Darier's disease, pityriasis rubra pilaris, ichthyosis, and palmoplantar keratoderma when administered orally. In this experiment, we compared the therapeutic and side effects between a group with high dose therapy(initially 75mg of etretinate a day) and an another group with low dose therapy(initially 40mg of etretinate a day). We also observed whether the pretreatment followed by combined treatment with vitamin E could potentiate the therapeutic effect as well as reduce the side effects of oral etretinate. This experiment comprised 102 moderate to severe psoriatic patients. The following results were obtained from this experiment. 1. Fifty-six among 92 patients(61%) who were treated with etretinate for more than 4 weeks showed good to excellent therapeutic effect. 2 The high dose therapy was more effective, but showed more side effects than low dose therapy. 3 Vitamin E did not potentiate the effect of etretinate. In low dose therapy, the pretreatment followed by combined treatment with vitamin E showed a tendency to reduce the side effects of etretinate.

Influence of Occlusive Dressing with Topical Corticosteroids on the Corneocytes of Normal Human Skin / 대한피부과학회지

This study was designed to investigate the effects of occlusive dressing with corticosteroid on the count, size and morphology of corneocytes of normal human skin. We select 16 male volunteers, aged 23 to 25 years, without skin lesions. They were divided to 2 groups according to duration of occlusive dressing, 3 days to group 1 and 6 days to group II. Specimens were obtained from 4 sites on the back, which were studied for the effect of occlusive dressings without any topicals, with 0.l% hydrocortisone-l7-butyrate cream, with 0.25% desoxymethasone ointment, and with base of desoxymethasone, before and every 3 to 5 days after occlusive dressings, up to a total 4 times in group I and 5 times in group II. (countinued..)

In Vitro antifungal Activities of Imidazole Derivatives / 대한피부과학회지

The present study was designed to obtain omparative data on in vitro antifungal activities of imidazole derivatives. Minimum inhibitory oncentrations of clotrimazole, miconazole, econazole, ketoconazlole and griseofulvin on 4 strains of Trichophyton mentagrophytes, 3 strains of Trichophyton rubrum, 2 strains of Microsporum canis and ] strain of Sporothriv: schenckii were etermined after 3 week' incubation at room temperature on Sabouraud's dextrose liquid media. In addition, the fungicidal activities of miconazole and econazole were tested against Z'richophyton mentagrophytes and Microsporum canis, using the techniques described by Vanbreuseghern(1967) The results are summarzed as follows: ] In most of the dermatophytes studied, 1 to 10 pg/ml of M1C were detected. Diverse susceptibility pattern was observed among different fungal species, but no or minor variability was noted within the same species. The susceptibility of Z'ri- chophyton rubrum showed at MIC of 0. 01 to 10 pg/ml, T ichophyton mentagro- phyt.es and Mic osporum canis at 0.1 to 10 pg/ml and 0. 1 to 1000 gg/ml respec- tively. The Trichophyton rubrum was the most sensitive. In the susceptibility test of Sporothrix schenckii, the high resistance to clotrimazole and griseofuhin was observed. The fungistatic activities of miconazole, econazole and ketoconazole were observed only at concentrations higher than JpQ pg/ml.

Two Cases of Angiokeratoma Circumscriptum / 대한피부과학회지

We report two cases of angiokeratoma circumcriptum. One of them was 20 year- old male, who had multiple dark erythematous 0.5 cm to 2 cm sized keratotic papules and nodules surrounding irregular shaped erythema scattered or grouped on the right lower leg. The other case was 36 year-old male, who had Q. 7 cm sized dark erythematous papules and 2 cm sized dark brown colored nodule with central ulceration on the medial part of the left upper thigh, The two patients had skin lesions at birth. Histopathologic finding disclosed markedly dilated vessels containing many red blood cells mainly in the papillary dermis, which in some, were surrounded by elongated rete ridge. Cavernous hemangioma like lesion was present in the lower dermis and subcutaneous fat in case 2.

Scanning Electron Microscopic Study of the Eccrine Ostia of Mouse Foot Pads After Application of Antiperspirant

Recently, a topical preparation of 5% propantheline bromide and 10% aluminum hydroxychloride in an emulsion ground substance was introduced as an effective antiperspirant. According to the literature, aluminum salts may produce functional closure of swet ducts. Nevertheless, histologic study has as yet failed to reveal a solid anatomic basis for occlusion. In this study, the scanning electron microscope (SEM) was used to demonstrate eccrine gland ostial occlusion due to topical 5% propantheline bromide and 10% aluminum hydroxychloride.

A Statistical Study of Dermatoses During the Last 5 Years (1976~1980) / 대한피부과학회지

The incidence of skin diseases in the hospital practice cannot give a true picture of their prevalence in the population served. Nevertheless the hospital incidence figures usually offer the only available means of assessing prevalence, and therefore provide us with a potentially valuable source of information on the ecology of many skin disorders. (countinued..)

13-cis-Retinoic Acid Treatment of Steroid Acne / 대한피부과학회지

No abstract available.

Two Case of Verrcous Hemangioma / 대한피부과학회지

Verrucous hemangioma is a variant of a capillary, cavernous, or mixed hemangioma which undergoes a reactive proliferative epidermal change. Most verrucous hemangiomas appear on the lower extremities, and most are present at birth or appear during childhood. We observed two patients who showed typical clinical and histopathological findings of verrucous hemangioma. Treatment was done by wide surgical excision and skin graft. The first rnale patient had a good therapeutic result but the second female patient had a recurrence at one month post-operative.

A Case of Scabies Combined with Superficial Dermatophytosis: affrevated by topical fluorinated steroid / 대한피부과학회지

A case of scabies combined with superficial dermatophytosis which was aggravated by application of topical fluorinated steroid for 6 months is presented. One year ago a 60-year-old male began to have pruritic erythematous papules on the lower abdomen which spread slowly to the inguinal and buttock area. He had had onychomycosis for six years and for the last 6 months he had applied a. fluorinated steroid. preparation. After application of steroid, the aggravated skin lesions spread rapidly over the whole body. A KOH mount showed sarcoptes scabiei and fungus. A count of itch mites from scales brushed off and collected from. the overall surface of the patients body showed 263 adults, 169 Iarvae and 534 eggs. T. rubrum from a culture of scales from the trunk and nails was confirmed. On admission FBS and oral GTT test revealed diabetic curve, however it could not be determined whether the diabetes mellitus was primary or secondary to the use of topical steroid application. The patient has been treated with crotamiton cream and antifungal agent with remarkably effective results.

IgE in atopic dermatitis / 대한피부과학회지

Serum IgE values were determined in 100 patients vith atogic dermatitis in the Department of Dermatology at Severance Hospital, Yonsei University College of Medicine, from Oct. 1, 1978 to Mar. 31, 1980. Mean IgE value of patients is 293. 4 unit/ml which is significantly higher than reference value, and the following results were obtained. 1. The mean IgE value in adults with atopic dermatitis, 339.8 unit/ml, 30 cases: more tian 16 years old) was significantly higher than in children(251. 4 unit /ml, 70 cases). 2. Male patierts showed higher IgE va,lue (mean 324. 5 unit/ml, 62 cases,' than female patients (242.7 unit/ml, 38 cases). 3. No close correlation was demonstrated between IgE values and eosiniphils in blood. 4. Patients with parasitic infesta,tion (5 cases) showed relatively increased IgE values (mean; 116. 2 unit/ml;. 5. Patients wifh bronchial asthma (2 cases) showed high IgE values exceeding 1000 unit/ml, 6. IgE. values roughly correlated with severity of the dermatitis. Four cases with high IgE values exceeding 1000 unit/ml were included in the clinically severe group.

A Case of Solar Urticaria / 대한피부과학회지

Solar urticaria is a fairly uncommon but Well recognized clinical entity characterized by erythema and wheal with itching immediately following exposure to sunlight or artifical radiation. A 33-year-old female had a six-year duration of urticaria, tightness of chest and dizziness that appeared within 15 minutes of exposure to sunlight. The action spectrum of this patient was between 320 and 400nm and the passive and reverse passive transfer test were negative. Solar urticaria of our patient appeared to belong to type g in the classification of Harber et al(1963). The patient was treated with antihistamines and repeated exposure to sunlight for inducing tolerance. After 3 months of the treatment, the symptoms did not appear even after 3 hours of exposure to sunlight.

Multiple Trichoepithelioma: Report of two cases / 대한피부과학회지

We observed 2 cases of multiple trichoepithelioma, which occured in 25-year- old male and 20-year-old female. They visited our department for multiple skin rashes on the face of 8 years duration in male and 7 years' duration in female patient. Both of them have similar skin lesions characterized by multiplel waxy gshiny, skin colored, firm papules scattered on the nasolabial folds, both eyelids and forehead. Each one of them has a history of similar skin lesions in the family. Literatures are briefly reviewed for discussion of clinical and histopathologicl findings in this disease.

Alternating Topical Treatment with Perinoic Acid And Retinoid (Ro 11 - 1430) on Acne Vulgaris: therapeutic effect and side reactions / 대한피부과학회지

The retinoic acid and retinoid(Ro 11-1430) were alternately applied topically on forty patients with acne vulgaris. Therapeutic effects and side reactions of this regimen were compared with our previous studies of the treatment with retinoic acid alone and with retinoid alone. Compared with the treatment with retinoic acid alone, the therapsutic effect of the alternating treatment was relatively superior as indicated by the markedly reduced severity of local side reactions.

Monilethrix with Keratosis Pilaris / 대한피부과학회지

Monilethrix is a rare hereditary disorder of hair which was described by smith in 1879. The scalp hair is most frequently affected but the body or sexual hair are rarely affected. The affected hair shows periodic constrictions that break easily, so the hair could not grow more than a few millimetere long. It is thought that the node of the affected hair is normal and the thin internodal segment is deficient in hair matrix. Keratosis pilaris is generally an associated feature. We experienced a case of monilethrix with keratosis pilaris. The 4 years old male patient with monilethrix affected only scalp hair with keratosis. The family history was non-contributory.